Pilot and Feasibility (P&F) Program

The overall objective of the University of Washington (UW) Nutrition Obesity Research Center Pilot and Feasibility (P&F) Program is to provide an infrastructure to support and effectively train the next generation of basic, translational, clinical and epidemiological scientists in the fields of nutrition, obesity and metabolism with a goal to enhance our knowledge and understanding of body weight regulation, the etiology and pathogenesis of nutrition-related disorders, to identify novel, therapeutic targets to prevent and treat obesity and to educate the broader community. The Specific Aims of the Program are to:

  • To provide junior investigators of high promise the opportunity to obtain crucial pilot data needed to launch their career and to compete successfully for independent peer-reviewed funding.
  • To provide a mechanism for encouraging talented junior investigators to embark on academic careers in nutrition/obesity research.
  • To support pilot projects by established investigators in other research fields into the area of nutrition and obesity research.

 

PILOT AND FEASIBILITY COLLABORATIVE PROGRAM 

The UW NORC collaborates with the Diabetes Research Center (DRC) and the UW Medicine Diabetes Institute (UWMDI) in a joint Pilot and Feasibility Research Program. The program collectively offers multiple awards of $50,000/year for up to 2 years to promising investigators from any disciplinary background performing research in the fields of nutrition, metabolism, diabetes, and obesity. Proposals may include basic, clinical, translational, or population-based studies that align with one or more of the institutions’ respective research themes. Awards are funded by the NIH (P30 grants DK017047 and DK035816) and the UW.

The next call for proposals will be Fall 2022 through the Joint Pilot and Feasibility Program comprised of the Nutrition Obesity Research Center (NORC), Diabetes Research Center (DRC) and the UW Medicine Diabetes Institute (UWMDI).

2022 UW NORC P&F RECIPIENTS:

AlongeDr. Kimberly Alonge, PhD, has been awarded a two-year Pilot and Feasibility Award through the UW Nutrition Obesity Research Center for her project entitled: “Role of hypothalamic PNNs in nutrient and hormone sensing dysfunction in obesity.”

Dr. Alonge received her PhD in Biochemistry and Molecular Biology at West Virginia University. She then conducted her postdoctoral studies at the University of Washington within the Department of Medicine in the laboratory of Dr. Michael W. Schwartz. Dr. Alonge was recently promoted to an Assistant Professor of Medicinal Chemistry with a joint appointment in the School of Medicine’s Division of Metabolism, Endocrinology and Nutrition at the University of Washington. Her research focuses on understanding the functional significance of extracellular matrix changes in metabolic and neurological diseases.

Project description: That obesity and type 2 diabetes (T2D) are among the most pressing and impactful biomedical challenges confronting modern society highlights the need for an improved understanding of the underlying disease mechanisms. Growing evidence suggests that the central nervous system transduces input from circulating hormones and nutrients into neuronal responses that maintain energy- and glucose- homeostasis and that dysfunction in this system contributes to the pathogenesis of obesity and T2D. Recent work from the Alonge laboratory has found that perineuronal nets (PNNs), which are specialized matrices that regulate the connectivity and activity of neurocircuits, enmesh key neurons involved in the regulation of energy- and glucose metabolism in the hypothalamic arcuate nucleus. Her work further shows loss of PNNs in both mouse models of diet-induced obesity and in obese and diabetic humans. Dr. Alonge hypothesizes that the obesity and diabetes-associated loss of hypothalamic PNNs results in altered diffusion of charged factors, including hormones, nutrients, and other metabolites, within this critical brain region resulting in hormone- and nutrient-sensing dysfunction characteristic to metabolic impairments. The concept that hypothalamic PNNs may play a key functional role in hypothalamic sensing of hormones and nutrients through changes in extracellular space diffusion dynamics, and that defects in metabolite diffusion may contribute to the obesity and T2D pathogeneses, constitutes an innovative area of research at the interface of metabolism and neuroscience with relevance to future therapy development.

ZaslavskyDr. Oleg Zaslavsky, PhD, MHN, RN, has been awarded a two-year Pilot and Feasibility Award for his project entitled: “Pilot Evaluation of a Mobile Intervention to Support Mediterranean Diet (MedD) for Persons with Mild Alzheimer Disease and Alzheimer Disease Related Dementia’s (AD/ADRD) and Frailty.”

Dr. Zaslavsky obtained his Bachelor of Science at the University of Haifa, Israel before completing his doctoral degree from the University of Washington School of Nursing focused on advanced statistics and frailty. Dr. Zaslavsky  is currently an Associate Professor  within the School of Nursing at the University of Washington. His research focuses on developing digital tools to promote health in older adults with frailty and dementia.

Project description:  Frailty, Alzheimer’s Disease (AD), and AD-related dementias are progressive conditions that disproportionally affect the same age group and share many risk factors and clinical features. Given that no treatments prevent or slow the progression of dementia, frailty might be a practical target for interventions to reduce the severity of the cognitive decline in persons with dementia. Lifestyle interventions such as healthy eating reduce risks of frailty and brain degeneration. The Mediterranean diet (MedD) is especially pertinent because of its cardioprotective, anti-inflammatory, and pro-metabolic properties, all of which are linked to the physiology of frailty and AD. In fact, observational and intervention studies have consistently shown that people adhering to MedD have less frailty, better brain morphology, and higher function. However, unfortunately, most MedD interventions are limited for implementation at the population level because of the high cost. This project is focused on the development of a mobile behavioral intervention to improve adherence to MedD for adults age 65 and older with mild-to-moderate frailty. The ultimate goal is to support population-level scalable and affordable interventions for secondary dementia risk reduction.

2022 UW NORC ADVANCE P&F RECIPIENTS:

JuarezDr. Barbara Juarez, PhD, has been awarded a one-year ADVANCE P&F Award, which targets early career scientists from underrepresented groups. The title of her project is: “Effect of a high-fat diet on VTA dopamine neuron activity and behavior.”

Dr. Juarez completed a Bachelor of Sciences Degree in Biological Sciences at Florida International University, Miami, FL before receiving her PhD in Neuroscience at Icahn School of Medicine at Mount Sinai, New York, NY. She is currently a postdoctoral research fellow in the Department of Psychiatry & Behavioral Sciences and Pharmacology at the University of Washington, Seattle WA in the laboratory of Dr. Larry Zweifel. Dr. Juarez studies the neural circuits that regulate reward seeking behaviors.

Project description: Overconsumption of high calorie, palatable food plays an important role in the etiology of obesity. Growing evidence suggests that this effect is mediated, in part, by the mesolimbic reward system which increases the drive and motivation of feeding behaviors. Specifically, the ventral tegmental area (VTA) receives input from brain regions involved in feeding and satiety and regulates dopamine release in the nucleus accumbens (NAc) to regulate reward. In the setting of high-fat, diet-induced obesity, dopamine signaling is reduced, while associations of cues and contexts to food reward is increased. Work from the Zweifel laboratory has recently found that corticotrophin releasing hormone receptor-1 (Crhr1) VTA dopamine neurons project to the NAc core and are critical to the ability to link cues and food reward associations, while cholecystokinin (Cck) VTA dopamine neurons project to the NAc mShell and are necessary for motivational drive for food reward. This project seeks to determine the effects of high-fat diet feeding on these VTA dopamine neuron subpopulations and if disrupting dopamine activity in these subpopulations impacts feeding behaviors.

ValenciaDr. Ana Valencia, PhD, has been awarded a one-year ADVANCE P&F Award, which targets early career scientists from underrepresented groups. The title of her project is: “The role of mitochondrial metabolism in weight loss in the context of obesity.”

Dr. Valencia received a doctorate in Kinesiology and Exercise Physiology in 2017 from the University of Maryland. She subsequently accepted a postdoctoral fellowship position at the University of Washington, Seattle WA in the laboratory of Dr. David Marcinek within the Department of Radiology. Dr. Valencia studies the effects of nutritional stress on mitochondrial function and metabolism

Project description: Weight loss reduces the burden of cardiometabolic risk factors in people with obesity and is currently one of the leading recommendations to improve metabolic health. However, following weight loss, the ability to further lose weight, let alone maintain weight loss is a common frustration amongst dieters and prevents long-term protection against cardiometabolic risk. Following behavioral weight loss, people experience a spontaneous weight loss plateau. During this period, it is difficult to lose more weight, and there is an increased susceptibility to regaining weight, thereby losing the cardiometabolic benefits. The physiology of the weight loss plateau is currently underexplored and may provide key insights into the mechanisms that make it challenging for people with obesity to achieve long-term metabolic health after weight loss. While waning adherence to prescribed diets likely contributes to a plateau, recent work from Dr. Valencia suggests an important role for mitochondrial function. Dr. Valencia hypothesizes that the plateau phase during weight loss is marked by reduced mitochondrial metabolism which increases the susceptibility to weight regain and cardiometabolic risk. To test this, Dr. Valencia will use a translational systems approach integrating clinical samples from NIH-funded weight loss studies in collaboration with Dr. Ellen Schur, with controlled animal studies to assess the relationship between mitochondrial function and energy expenditure and cardiometabolic risk in collaboration with Drs. Gregory Morton and Karin Bornfeldt.

2021 UW NORC P&F recipient:

Dr. Meghan Koch, PhD, has been awarded a two-year Pilot and Feasibility Award for her project entitled: “Regulation of white adipose tissue function and energy balance by breastmilk antibodies.”

Dr. Koch received a doctorate in immunology in 2010 from the University of Washington. She conducted postdoctoral studies at the University of California, Berkeley from 2011 to 2018, when she accepted a position as an assistant professor in the Basic Sciences Division at the Fred Hutchinson Cancer Research Center. Dr. Koch’s group studies maternal-offspring interactions, focusing on immunity, metabolism and the microbiota.

Project description: Accumulating epidemiological studies link breastfeeding with long-term metabolic health, yet the mechanisms underlying this association remain unclear. Using a mouse model system, Dr. Koch’s group recently identified maternal antibodies, transmitted via breastfeeding, as an essential regulator of healthy metabolism in offspring.  Offspring that do not receive maternal antibodies exhibit persistent perturbations in lipid homeostasis, including reduced adiposity, impaired glucose homeostasis and insulin resistance. This project seeks to understand the mechanisms linking this early life process (acquisition of breastmilk antibodies) with durable health outcomes (lipid homeostasis and insulin resistance). Breastmilk antibodies coat commensal bacteria in the guts of suckling offspring and mediate the initial host-microbiota interactions in neonates. Dr. Koch’s research has found that in the absence of breastmilk antibodies, neonates mount inappropriate adaptive immune responses to beneficial gut microbes. Owing to the ability of adaptive immune cells to form memory responses that persist throughout the life of the host, she hypothesizes that these dysregulated early life immune responses drive persistent impairments in metabolic function. Here, the Koch laboratory will characterize the metabolic dysfunction exhibited by offspring that don’t acquire breastmilk antibodies and assess the contribution of early life, dysregulated adaptive immune responses toward these long term metabolic impairments.

Previous UW NORC P&F Program Awardees

Jarrad Scarlett, MD, PhD
Jarrad Scarlett, MD, PhD

Department of Pediatrics
Hypothalamic Mechanisms of FGF1-Mediated Remission of Diabetic Hyperglycemia
07/01/2016 - 06/30/2018

Mauricio Dorfman, PhD
Mauricio Dorfman, PhD

Department of Medicine
The Role of CNS CX3CL1-CX3CR1 Signaling in Estrogen-Mediated Protection Against Obesity and Diabetes
07/01/2015 - 06/30/2017

Jenny Kanter, PhD
Jenny Kanter, PhD

Department of Medicine
A Novel Model of Type 2 Diabetes-accelerated Atherosclerosis
07/01/2014 - 06/30/2016

Davene Wright, PhD
Davene Wright, PhD

Department of Pediatrics
Parent Attitudes Toward Child Health and Weight
07/01/2014 - 06/30/2016

Michelle Averill, PhD
Michelle Averill, PhD

Department of Environmental and Occupational Health Sciences
The Effects of Dietary Glycemic Load on Postprandial Lipemia and HDL Composition and Function
07/01/2013 - 06/30/2015

Laura den Hartigh, PhD
Laura den Hartigh, PhD

Department of Medicine
Trans-10, Cis-12 Conjugated Linoleic Acid Enhances Lipid Utilization in Adipocytes by Increasing Mitochondrial Metabolism and Insulin Resistance
07/01/2012 - 06/30/2014

Katya Rubinow, MD
Katya Rubinow, MD

Department of Medicine
Androgen-mediated Pathway in the Regulation of Insulin Sensitivity in Men
07/01/2012 - 06/30/2014

Joshua Thaler, MD, PhD
Joshua Thaler, MD, PhD

Department of Medicine
The Development Role of PPAR-y in Adult Metabolism
07/01/2011 - 06/30/2013

Mario Kratz, PhD, MS
Mario Kratz, PhD, MS

Department of Epidemiology and Medicine
Vitamin D and Low-grade Adipose Tissue Inflammation
07/01/2011 - 06/30/2013

Tomas Vaisar, PhD
Tomas Vaisar, PhD

Department of Medicine
Effects of Omega-3 Polyunsaturated Fatty Acid Diet Supplementation on HDL and its Biological Activity
07/01/2009 - 06/30/2011

Carole Wilson, PhD
Carole Wilson, PhD

Medical University of South Carolina
ADAM17-mediated Proteolysis in Diet-induced Obesity
07/01/2009 - 06/30/2011

Andrew Hoofnagle, MD, PhD
Andrew Hoofnagle, MD, PhD

Department of Laboratory Medicine
HDL and Cardiovascular Risk in Chronic Kidney Disease
07/01/2007 - 06/30/2009


Program Leadership

Greg Morton, PhD
Greg Morton, PhD

Program Director gjmorton@uw.edu